All Categories


Time: 2020-06-01 hits: 543

Serological surveys can aid investigation of an ongoing outbreak and retrospective assessment of the attack rate or extent of an outbreak. In cases where viral testing is negative and there is a strong epidemiological link to virus infection, paired serum samples (in the acute and convalescent phase) could support diagnosis once validated serology tests are available. Serum samples can be stored for these purposes.

Serology tests detect the presence of antibodies in the blood when the body is responding to a specific infection, like virus. In other words, the tests detect the body’s immune response to the infection caused by the virus rather than detecting the virus itself. In the early days of an infection when the body’s immune response is still building, antibodies may not be detected. Recent study shows the incubation period of SARS-COV-2 would be nearly 7-14 days, and antibody could be detected about nearly 14 days after onset. (cause the immune response in the human body takes a period of time to generate specific antibodies, if the detection is performed during the window period before antibody production, there may be cases of false negative).

 [1] Page 22, MEDRXIV Posted March 03,2020. htps://doi. org/10.1101/2020.03.02.20030189

This limits the test’s effectiveness for diagnosing virus, and this is one reason serology tests should not be used as the sole basis to diagnose virus. Serology tests could play a role in the fight against virus by helping healthcare professionals identify individuals have developed an immune response to SARS-CoV-2. In addition, these test results can aid in determining who may donate a part of their blood called convalescent plasma, which may serve as a possible treatment for those who are seriously ill from virus. If conditional, suspected cases should be screened for the combination of virology and serological testing,and also computed tomography.