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SAA & CRP apply to novel coronavirus pneumonia(NCP) screening

Sij hawm: 2020-02-12 Hits: 63

Since the novel coronavirus' outbreak in Wuhan, China, Chinese government along with all the Chinese people are taking our utmost efforts to win the battle against the novel coronavirus epidemic.


Coronavirus cases and all suspected cases of novel coronavirus infection are calling for timely and effective diagnosis, quarantine, and treatment.


According to the latest treatment plan for novel coronavirus pneumonia (NCP), released by National Health Commission, said that most of the infected patients’ C-reactive protein (CRP) level are higher than un-infected group, procalcitonin (PCT) level is normal; D-Dimer level will rise among the severe cases.


At the same time, some study shows that be similar to CRP, serum amyloid A(SAA) is a sensitive reactant in the acute phase too. CRP & SAA level in the blood is an important indicator reflecting the level of the inflammation of patients. The testing of inflammation via CRP & SAA can be speeded up and the real-time signal read-out has a great potential in allowing the doctors to take necessary immediate actions.


To the novel coronavirus-infected patients, the SAA level increased greatly during the early infection, what’s more, SAA & CRP level will both fluctuated along with the inflammation disease progresses; After the novel coronavirus turns negative, SAA decreases significantly until it returns to normal.


As it has been confirmed that novel coronavirus can be transmitted from person to person, usually after close contact with an infected patient, quarantine is recommended to curb spread urgently. How about the large majority of suspected cases? These suspected patients should be encouraged to visit community-level medical institutions to reduce the overwhelmed burden of large hospitals and reduce the risk of secondary transmission.


Combined with CRP+SAA test, even if the NCP does not have obvious symptoms, fever or cough, but the SAA level in the body is exceed than the normal, can effectively reduce the rate of misdiagnosis in advance.