PT APTT TT FIB - კოაგულაციის სწრაფი რეაგენტის ნაკრები

მიმოხილვა

[ელ.ფოსტით დაცულია] The APTT/PT/TT/FIB Reagent Kit is intended to measure the activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and quantitatively determine fibrinogen (FIB).

Clinically, it is mainly used to screen the intrinsic and extrinsic deficiencies of coagulation system, reflect the content or structure abnormality of plasma fibrinogen and the abnormality in fibrinolytic system. It can also be used for the auxiliary diagnosis of disseminated intravascular coagulation and primary fibrinolysis, monitor the oral anticoagulant treatment, heparin anticoagulant therapy and thrombolytic therapy.

Დანიშნულებისამებრ გამოყენების

Activated partial thromboplastin time (APTT) is a screening test for the detection of intrinsic coagulation factors. It can be used to detect the deficiencies to the inherited or acquired factors (VIII, IX or XI) or detect the presence of its corresponding inhibitors. APTT can also be used to prove the lacking of coagulation XII, prokallikrein and high molecular weight kallikrein. APTT is the preferred measure of monitoring unfractionated heparin.

Clinically, prothrombin time (PT) is mainly used to screen the extrinsic deficiencies of coagulation system and monitor oral anticoagulant treatment. With prolonged PT, there may be inherited  factor II,V,VII,X deficiencies and hypofibrinemia (or afibrinogenemia); The lacking of acquired coagulation factor is found in DIC, primary fibrinolytic hyperactivity, obstructive jaundice and  vitamin K deficiency; with shortened PT, there may be inherited factor V excess, oral contraceptives, hypercoagulability and thrombotic diseases.

Thrombin time (TT) is a screening test to access the ability of plasma fibrinogen to transform to fibrinogen. With prolonged TT, there may be increased heparin, existence of multiple heparin anticoagulant, such as hepatopathy, renal diseases, etc.; hypofibrinemia (or afibrinogenemia), abnormal frinogenemia, increased FDP, such as DIC, primary fibrinolysis, etc. With shortened TT, there may be tiny blood clots or Ca+ in blood sample.

Elevated fibrinogen (FIB) is usually found in highly coagulated blood, which is observed in diabetes patients with vascular disease, or patients with acute myocardial infarction, cerebrovascular disease, and pregnancy induced hypertension, etc. Reduced fibrinogen is usually found in patients with DIC (consumptive coagulopathy or fibrinolysis), primary fibrinolytic disease, serious hepatitis, hepatic cirrhosis, inherited hypofibrinemia (or afibrinogenemia), etc.

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